Chromosomal Instability in Acute Myelocytic Leukemia and Myelodysplastic Syndrome Patients among Atomic Bomb Survivors

Cytogenetic Instabilities in Atomic Bomb-Related Acute Myelocytic Leukemia Cells and in Hematopoietic Cells from Healthy Atomic Bomb Survivors

On August 6 and 9, 1945, nearly 65 years ago, atomic bombs (ABs) were dropped on two Japanese cities, Hiroshima and Nagasaki. The explosive powers of these two bombs are said to be equal about 12.5 kilotons of TNT for Hiroshima bomb and 22 kilotons for Nagasaki bomb. The dissipation of energy is believed to have been in the ratios consisting of 50% of bomb blast, 35% of thermal rays and 15% of ...

Leukemia in Atomic Bomb Survivors

EUKEMOGENESIS induced by repeated exposures to x-ray and other forms of radiation energy has long been recognized in man and in experimental ammals.’3 The explosion of the atomic bombs in Japan exposed two large human populations to single brief but massive doses of ionizing irradiation and subsequently a marked increase in leukemia among survivors was reported.4 ‘ The present study consists of...

Leukemia in Hiroshima atomic bomb survivors.

A CAUSAL RELATION between radiation and leukemia has been well demonstrated.112 The reported cases of leukemia in people exposed to radium, 1.’I 4 1 occupational x-ray,’ I therapeutic x-ray to the thyroid region in childhood’92#{176} and possibly in utero diagnostic x-ray,2’ have been few in number. Estimates of the increased risk associated with exposure of man to radiation depend heavily upon...

Leukemia in offspring of atomic bomb survivors.

P ERSISTENT CHROMOSOMAL ABERRATIONS have been reported in survivors of Hiroshima and Nagasaki who were under 30 years of age and within 1500 meters from the hypocenter at the time of the bombs ( ATB ).‘ Extensive surveillance of the progeny of exposed survivors has failed to demonstrate any increase in the risk of mortality or congenital malformation or any alteration of the sex ratio.2 However...

Atomic bomb injuries among survivors in Hiroshima.